T cell Senescence 249 3
نویسندگان
چکیده
1. Abstract 2. Introduction 3. Age-associated alterations in T cell function 4. T cell subsets 4.1. Other subset alterations: TH1 vs. TH2, Rhodamine 123 vs. R123, CD8 CD122 5. Thymus 5.1.Involution 5.2. Thymic productivity 6. Lifespan and homeostasis of T cell populations 6.1. Replicative senescence and sensitivity to apoptosis 7. T cell activation 7.1. TCR signaling 7.2. Costimulation 8. Influences of the aged environment 8.1. Cytokines 8.2. APC 9. Concluding remarks 10. Acknowledgements 11. References
منابع مشابه
Looking for immortality: Review of phytotherapy for stem cell senescence
Objective(s): In this paper, we discussed natural agents with protective effects against stem cell senescence. Different complications have been observed due to stem cell senescence and the most important of them is “Aging”. Senescent cells have not normal function and their secretary inflammatory factors induce chronic inflammation in body which causes different patho...
متن کاملCorneal Endothelial Cells Provide Evidence of Accelerated Cellular Senescence Associated with HIV Infection: A Case-Control Study
BACKGROUND Cellular senescence may be a key factor in HIV-related premature biological aging. We assessed features of the corneal endothelium that are known to be associated with biological aging, and cellular senescence markers in HIV-infected adults. METHODS Case-control study of 242 HIV-infected adults and 249 matched controls. Using specular microscopy, the corneal endothelium was assesse...
متن کاملThe Lcn2-engineered HEK-293 cells show senescence under stressful condition
Objective(s): Lipocalin2 (Lcn2) gene is highly expressed in response to various types of cellular stresses. The precise role of Lcn2 has not been fully understood yet. However, it plays a key role in controlling vital cellular processes such as proliferation, apoptosis and metabolism. Recently it was shown that Lcn2 decreases senescence and increases proliferation of mesenchymal stem cells (MSC...
متن کاملIn Vitro Evaluation of Protective Effect of Rutin on Acrylamide-Induced Cellular Senescence in NIH3T3 Cells
Background: Aging is one of the important factors in the development of age-related diseases. Acrylamide can be produced during carbohydrate-rich foods prepared at high temperatures. Recently, studies showed that acrylamide can induce cellular senescence. On the other hand, Rutin as a natural flavonoid, has a potent antioxidant activity. Objective: This study aims to evaluate the ptotective ef...
متن کاملMolecular genetic control of leaf lifespan in plants - A review
Leaf senescence constitutes the last stage of leaf development in plants and proceeds through a highly regulated program in order to redistribution of micro- and macro-nutrients from the senescing leaves to the developing/growing plant organs. Initiation and progression of leaf senescence is accompanied by massive sequential alterations at various levels of leaf biology including leaf morpholog...
متن کامل